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目的模拟实际居住环境,探讨不同装修水平胶合板(胶合板释放物主要为甲醛)连续7、14、28 d暴露对小鼠体液免疫功能的影响。方法雌性BALB/c小鼠分别暴露于不同装修水平的胶合板:10倍装修水平组[甲醛含量(3.46±0.260)mg/m3]和3倍装修水平组[甲醛含量(1.03±0.18)mg/m3],吸入染毒,5 h/d,分别暴露7、14、28 d,另设正常对照组[空气吸入,甲醛含量为(0.05±0.02)mg/m3]。实验结束时进行体液免疫功能检测。结果胶合板释放物染毒7 d,3倍、10倍装修水平组,28d10倍装修水平组,小鼠半数溶血值(HC5)0较对照组降低,差异有统计学意义(P<0.05或P<0.01)。同时,14d及28d 10倍装修水平组溶血空斑数较对照组降低,差异有统计学意义(P<0.05)。结论胶合板释放物甲醛对小鼠体液免疫功能有抑制作用。
Objective To simulate the actual living environment and investigate the effects of different levels of plywood (mainly formaldehyde released) on the humoral immune function in mice after 7, 14 and 28 d of exposure. Methods Female BALB / c mice were exposed to different levels of plywood decoration: formaldehyde level (3.46 ± 0.260 mg / m 3) and decorate level (formaldehyde level 1.03 ± 0.18 mg / m 3 ], Inhalation exposure, 5 h / d, were exposed 7,14,28 d, another set of normal control group [air inhalation, formaldehyde content of (0.05 ± 0.02) mg / m3]. At the end of the experiment humoral immune function test. Results The half-value hemolysis (HC5) 0 of plywood release was significantly lower than that of the control group (P <0.05 or P <0.05 or P < 0.01). At the same time, the number of hemolysis plaques in 10-day refurbishment group was significantly lower than that in control group on 14d and 28d, with significant difference (P <0.05). Conclusions Formaldehyde released from plywood can inhibit humoral immune function in mice.