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IL 16主要来自CD8+ T淋巴细胞 ,它的受体是CD4分子。近来许多实验证实IL 16在体外有抑制人免疫缺陷病毒增殖的生物活性。其作用机制一为通过对抗NF κB和Tat所致的活化转录作用 ,从而影响人免疫缺陷病毒启动子的活性而抑制免疫缺陷病毒的转录。另一机制为下调CD95的表达 ,抑制T淋巴细胞活化后诱导的T淋巴细胞凋亡 ,从而增加T淋巴细胞的数目 ,为免疫缺陷病毒感染者的综合治疗提供了新的途径。
IL 16 is predominantly CD8 + T lymphocytes and its receptor is a CD4 molecule. Recently, many experiments confirmed that IL-16 has the biological activity of inhibiting the proliferation of human immunodeficiency virus in vitro. Its mechanism of action is to inhibit the transcription of immunodeficiency virus by affecting the transcriptional activation of NFκB and Tat and thus affecting the activity of human immunodeficiency virus promoters. The other mechanism is to downregulate the expression of CD95 and inhibit T lymphocyte activation induced T lymphocyte apoptosis, thereby increasing the number of T lymphocytes, which provides a new way for the comprehensive treatment of patients with immunodeficiency virus infection.