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2型糖尿病为影响人类生存质量的主要病因之一,在过去十年里,2型糖尿病在全球范围的发病率显著增加~([1])。其主要特征是胰岛素相对不足和存在胰岛素抵抗。2型糖尿病的胰岛素抵抗作用和人体肝脏、骨骼肌及脂肪组织中的胰岛素信号转导通路紊乱关系密切~([2])。经典的胰岛素信号转导有胰岛素受体底物1(insulin receptor substrate 1,IRS-1)/磷脂酰肌醇3-激酶
Type 2 diabetes is one of the major causes of the quality of life in humans and has been associated with a significant increase in the global incidence of type 2 diabetes in the past decade (1). Its main feature is the relative lack of insulin and the presence of insulin resistance. Insulin resistance in type 2 diabetes is closely related to disturbances in the insulin signaling pathways in human liver, skeletal muscle and adipose tissue ~ ([2]). Classical insulin signaling has insulin receptor substrate 1 (IRS-1) / phosphatidylinositol 3-kinase