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目的:检测鼻腔鼻窦内翻性乳头状瘤(NIP)组织中CCAAT增强子结合蛋白α(C/EBPα)、CK10的表达,进一步探讨其在NIP发生、发展及复发中的作用。方法:应用免疫组织化学PV-6000二步法检测30例NIP组织、20例鼻息肉(NP)组织和10例正常鼻黏膜(NM)组织中C/EBPα、CK10的表达。结果:1NM、NP与NIP组织中C/EBPα、CK10的阳性表达均差异有统计学意义(均P<0.05);2单纯NIP组与不典型增生NIP组中C/EBPα、CK10的阳性表达差异有统计学意义(P<0.05);3复发NIP组与未复发NIP组中C/EBPα、CK10的阳性表达率差异有统计学意义(P<0.05);4NIP组中C/EBPα和CK10的表达呈正相关(r=0.578,P<0.01)。结论:C/EBPα、CK10在NIP上皮增殖与分化的调控中可能起了重要作用,C/EBP-α和CK10的高度表达可作为NIP复发的指标。
Objective: To detect the expression of CCAAT enhancer binding protein α (C / EBPα) and CK10 in nasal inverted papilloma (NIP) tissues and to explore its role in the occurrence, development and recurrence of NIP. Methods: The expressions of C / EBPα and CK10 in 30 cases of NIP, 20 cases of nasal polyps (NP) and 10 cases of normal nasal mucosa (NM) tissues were detected by immunohistochemistry PV-6000 two-step method. Results: The positive expressions of C / EBPα and CK10 in 1NM, NP and NIP tissues were significantly different (all P <0.05). The positive expressions of C / EBPα and CK10 in 2 NIP group and atypical hyperplastic NIP group were significantly different (P <0.05). The positive expression rates of C / EBPα and CK10 in 3 relapsed NIP group and non-relapse NIP group had statistical significance (P <0.05). The expressions of C / EBPα and CK10 in 4NIP group (R = 0.578, P <0.01). CONCLUSION: C / EBPα and CK10 may play an important role in the regulation of NIP epithelial proliferation and differentiation. The high expression of C / EBP-α and CK10 may be used as indicators of NIP recurrence.