【摘 要】
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Objective: To deeply explore the molecular mechanism of MCLR in the course of MCLR promoting liver tumor. Methods: We applied the two -stage- medium-term theory
【机 构】
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Institute of Virology, Fujian Agriculture and Forestry University, Fuzhou 350002, China;Public Healt
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Objective: To deeply explore the molecular mechanism of MCLR in the course of MCLR promoting liver tumor. Methods: We applied the two -stage- medium-term theory to set up the animal model, and biochemistry technique to evalu-ate the model, and then, used RT-PCR technique and image analysis to study the mRNA expression of the p53 and p16 in the course of promoting tumor. Results: (1) MCLR could enhance the positive reaction ratio of y-Glutamyltransferase(GGT). (2) MCLR could increase the mRNA expression of p53, and had not effect on the mRNA expression of p53. Conclusion: (1) MC can promote liver tumor strongly. (2) The expression change of p53 may play an important role in the course of MCLR promoting liver tumor.
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