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目的:观察补充外源性抗氧化剂对急性心脑血管意外老年病人血浆谷胱甘肽过氧化物酶(GSH-Px)的活性、维生素A(VitA)、维生素C(VitC)、维生素E(VitE)和硒(Se)水平的影响。方法:对105例急性心脑血管意外老年病人随机分为试验组(加用抗氧化剂)和对照组(服用安慰剂)。两组病人均每天服用1次,连续6周。两组病人在治疗前、治疗后3周和6周,清晨空腹采取肘静脉血3 ml。检测血浆GSH-Px活性、VitA、VitC、VitE和Se的水平变化。结果:治疗3周和6周后,试验组病人血浆GSH-Px活性,VitC、VitE和Se水平较对照组明显升高(P<0.05)。试验组病人治疗6周后VitA水平较对照组明显升高(P<0.05)。结论:对急性心脑血管意外老年病人补充外源性抗氧化剂,可在短时间内增加血浆VitA、VitC、VitE、Se的含量和GSH-Px的活性。
Objective: To observe the effects of exogenous antioxidants on the plasma glutathione peroxidase (GSH-Px) activity, the levels of vitamin A (VitA), vitamin C (VitE) and vitamin E (VitE) in elderly patients with acute cardiovascular and cerebrovascular accident. ) And selenium (Se) levels. Methods: 105 elderly patients with acute cardiovascular and cerebrovascular accident were randomly divided into experimental group (with antioxidant) and control group (placebo). Two groups of patients were taken once daily for 6 weeks. Two groups of patients before treatment, 3 weeks and 6 weeks after treatment, fasting morning to take cubital vein blood 3 ml. Plasma GSH-Px activity, VitA, VitC, VitE and Se levels were measured. Results: After 3 weeks and 6 weeks of treatment, the levels of GSH-Px, VitC, VitE and Se in the test group were significantly higher than those in the control group (P <0.05). After 6 weeks of treatment, the VitA level in the experimental group was significantly higher than that in the control group (P <0.05). CONCLUSION: Supplementation of exogenous antioxidants in elderly patients with acute cardiovascular and cerebrovascular accidents can increase the contents of VitA, VitC, VitE, Se and the activity of GSH-Px in a short period of time.