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自发现雷公藤有抗生育作用以来,临床医生大都将其视为毒副作用并受到重视。随着这方面研究的不断深化,人们逐步认识到这种抗生育作用存在着剂量依赖性和可逆性。因此,从节制生育的角度出发,雷公藤很有可能发展成为一种节育新药,现将有关雷公藤抗生育作用的临床及实验研究情况综述如下。一、临床研究(一)抗男性生育作用1.对精子的影响分别给86例具有生育功能的类风湿性关节炎等病的患者,口服常规剂量雷公藤粗制剂(粗提物)或小剂量雷公藤多甙(GTW),时间短者仅数日,长者达9年,多数为2个月～2年。用药前,检查部分患者精液,均在正常范围内;用药后所
Since the discovery of the anti-fertility effects of Tripterygium wilfordii, most clinicians have regarded it as a toxic side effect and have been valued. With the continuous deepening of research in this area, people gradually realized that this anti-fertility effect was dose-dependent and reversible. Therefore, from the perspective of birth control, Tripterygium wilfordii is likely to develop into a new birth control medicine. The clinical and experimental studies on the anti-fertility effects of Tripterygium wilfordii are summarized below. I. Clinical research (A) Anti-male fertility effects 1. Effects on spermatozoa 86 cases of rheumatoid arthritis patients with fertility were treated with conventional oral doses of crude Tripterygium wilfordii (crude extract) or small doses. The GTW is only a few days short and the elders are 9 years old, with a majority of 2 months to 2 years. Before treatment, check the semen of some patients, all within the normal range; after medication