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目的:对羌独祛湿止痛汤联合来氟米特对类风湿性关节炎的临床疗效进行探讨。方法:将90例类风湿性关节炎患者随机分为对照组和观察组,每组各45例。对照组给予口服来氟米特,20 mg/d,观察组在此基础上加以中药汤剂羌独祛湿止痛汤,每日1剂。治疗3个月后观察其血液指标、中医证候积分变化,并据此对两组的临床疗效进行比较分析。结果:治疗后与对照组相比,观察组血沉(ESR)、类风湿因子(RF)、C-反应蛋白(CRP)水平及中医证候积分均明显降低,主要症状体征改善率显著提高,且临床疗效也明显优于对照组,差异均具有统计学意义(P<0.05)。在不良反应方面,观察组发生率相比对照组有所降低,但差异并不具有统计学意义(P>0.05)。结论:羌独祛湿止痛汤联合来氟米特治疗可有效改善患者的临床症状,提高临床疗效,对控制患者不良反应也有着积极的作用。
Objective: To investigate the curative effect of QWD Qushi Decoction combined with leflunomide on rheumatoid arthritis. Methods: 90 patients with rheumatoid arthritis were randomly divided into control group and observation group, 45 cases in each group. The control group was given oral leflunomide, 20 mg / d, on the basis of which the observation group was given Qiangdu Qushi Decoction alone and once daily. After 3 months of treatment, the blood indexes and TCM syndrome scores were observed, and the clinical efficacy of the two groups were compared and analyzed. Results: Compared with the control group, the ESR, RF, C-reactive protein (CRP) levels and TCM syndrome scores of the observation group were significantly decreased and the improvement rate of the main symptoms and signs was significantly increased after treatment Clinical efficacy was also significantly better than the control group, the differences were statistically significant (P <0.05). In adverse reactions, the incidence of observation group compared with the control group decreased, but the difference was not statistically significant (P> 0.05). Conclusion: QWD Qushi Decoction combined with leflunomide treatment can effectively improve the clinical symptoms of patients and improve clinical efficacy, and has a positive effect on the control of adverse reactions in patients.