Repurposing of antitumor drug candidate Quisinostat lead to novel spirocyclic antimalarial agents

来源 :中国化学快报:英文版 | 被引量 : 0次 | 上传用户：kissall79

【摘要】

：

Antimalarial chemotherapies endowed with effectiveness against drug-resistant parasites and good safety are urgently required in clinical.Our previous research revealed that clinical phaseⅡantitumor drug Quisinostat was a promising antimalarial prototype

【作者】

：

Ruoxi Li Dazheng Ling Tongke Tang Zhenghui Huang Manjiong Wang Fei Mao Jin Zhu Lubin Jiang Jian Li Xiaokang Li

【机构】

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StateKeyLaboratoryofBioreactorEngineering,KeyLaboratoryofMolecularVirologyandImmunology,CollegeofPha

【出处】

：

中国化学快报:英文版

【发表日期】

：

2021年5期

【关键词】

：

MALARIA PfHDAC inhibitor Drug repurposing Epigenetic modulator Erythrocytic ther

【基金项目】

：

This work was supported by the National Key R&D Program of China(Nos.2017YFB0202600,2018YFA0507300),the National Mega-project for Innovative Drugs of China(No.2019ZX09721001-004-003),the National

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Repurposing of antitumor drug candidate Quisinostat lead to novel spirocyclic antimalarial agents

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