用原子吸收法测定枸橼酸铋锌钠中铋在狗体内药代动力学，铋呈现二室动力学模型．其药物动力学参数，静脉给铋０．５３３ｍｇ／ｋｇ，Ｔ１／２β为３．５６ｈ，ＡＵＣ为３．７８（μｍｏｌ／Ｌ）·ｈ．灌胃给铋６．６６，１３．３３和２０．０ｍｇ／ｋｇ三个剂量，Ｔ１／２β分别为３１．５８，３１．４２和３４．０８ｈ；ＡＵＣ为４．１２，４．９３和６．５１（μｍｏｌ／Ｌ）·ｈ；Ｔｐ为３．４６，２．３６和１．９８ｈ；Ｃｍａｘ为０．１０，０．２４和０．３３μｍｏｌ／Ｌ．用静脉注射和灌胃的中剂量ＡＵＣ统计铋的生物利用度为５．２２％．结果提示，铋胃肠吸收极少，生物利用度低，大部分从胃肠道排出体外． The bovine pharmacokinetics of bismuth in sodium bismuth zinc citrate were determined by atomic absorption spectrometry, and bismuth exhibited a two-compartment kinetic model. Its pharmacokinetic parameters were 0.533mg / kg intravenous bismuth, T1 / 2β 3.56h, and AUC 3.78 (μmol / L) · h. The three doses of bismuth 6.66, 13.33 and 20.0 mg / kg were intragastrically administered with T1 / 2β of 31.58, 31.42 and 34.08 h, respectively; AUC of 4.12, 4.93 and 6. 51 (μmol / L) · h; Tp was 3.46, 2.36 and 1.98 h; Cmax was 0.10, 0.24 and 0.33 μmol / L. The bioavailability of bismuth was 5.22% measured by medium dose AUC intravenous and intragastric administration. The results suggest that bismuth gastrointestinal absorption is minimal, low bioavailability, most of the excreted from the gastrointestinal tract.