Objective:To investigate the effects of an aqueous leaf extract of Acalypha wilkesiana (A.wilkesiana) on plasma chemistry and hematological indices of sub-chronic salt-loaded rate. Method:The control group received a diet consisting 100%of the commercial feed,while the four test groups were received a diet consisting 8%salt and 92%commercial feed all through, except for the reference treatment group that had its salt-loading discontinued after six weeks. The extract was orally administered daily at 200 and 250 mg/kg body weight;while the test control,reference and control groups received appropriate volumes of water by the same route. Results:The extract had no negative effects on markers of liver and kidney functions,produced hemoconcentration,significantly higher(P<0.05) plasma calcium and potassium levels,and significantly lower(P<0.05) plasma sodium and chloride levels in the test animals compared to test control.Conclusions:This result supports the traditional use of A.wilkesiana in the management of hypertension and suggesls that the extract may be a potassium sparing diuretic whose mechanism of antihypertensive action may be via alteration of plasma sodium and potassium balances or calcium mediated alteration in vascular muscle tone. Objective: To investigate the effects of an aqueous leaf extract of Acalypha wilkesiana (A. wilkesiana) on plasma chemistry and hematological indices of sub-chronic salt-loaded rate. Method: The control group received a diet consisting of 100% of the commercial feed, while the four test groups were received a diet consisting of 8% salt and 92% commercial feed all through, except for the reference treatment group that had its salt-loading discontinued after six weeks. The extract was orally administered daily at 200 and 250 mg / while the test control, reference and control groups received the appropriate volumes of water by the same route. Results: The extract had no negative effects on markers of liver and kidney functions, produced hemoconcentration, significantly higher (P <0.05) plasma calcium and potassium levels, and significantly lower (P <0.05) plasma sodium and chloride levels in the test animals compared to test control. Conclusions: This result supports the traditional use of A. wilkesiana in the management of hypertension and suggesls that the extract may be a potassium sparing diuretic whose mechanism of antihypertensive action may be via alteration of plasma sodium and potassium balances or calcium mediated alteration in vascular muscle tone.