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目的探讨颅内肿瘤切除术后颅内感染的影响因素。方法收集479例颅内肿瘤接受开颅手术患者的临床资料,对术后颅内感染的相关因素进行单因素和多因素分析。结果 479例患者的颅内感染率为13.78%。单因素分析结果显示,年龄≤45岁、做后颅窝手术、乳突气房或窦开放手术和手术时间>3h的患者颅内感染率均高于年龄>45岁、未做后颅窝手术、乳突气房或窦开放手术和手术时间≤3h者(P<0.05)。Logistic回归分析结果显示:年龄越小、做过后颅窝手术的患者越容易得颅内感染。结论可通过后颅窝手术中严密缝合硬脑膜或改进手术入路方式等有效降低颅内肿瘤切除术后颅内感染的发生率。
Objective To investigate the influencing factors of intracranial infection after intracranial tumor resection. Methods The clinical data of 479 patients with intracranial tumors undergoing craniotomy were collected. Univariate and multivariate analyzes were performed on the related factors of postoperative intracranial infection. Results The 479 patients had intracranial infection rate of 13.78%. Univariate analysis showed that the rates of intracranial infection in patients who were aged 45 years or less after posterior fossa operation, mastoid atrium or open sinus surgery and operation time> 3h were higher than those of patients> 45 years of age without posterior fossa operation , Mastoid atrium or open sinus surgery and surgery time ≤ 3h (P <0.05). Logistic regression analysis showed that the younger the patients, the more posterior cranial fossa surgery patients with intracranial infection more easily. Conclusions The incidence of intracranial infection after intracranial tumor resection can be effectively reduced through strict suture of dura mater or improved operation approach in posterior fossa operation.