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重症肌无力(MG)是一种病因不明的疾病, 其发病机理为神经肌肉接头处对乙酰胆硷受体(AchR)的自身免疫反应,对于这一机理的证实是基于以下事实:MG患者存在体液抗体以及对AchR特殊细胞介导的免疫反应的证实;神经肌肉接头处抗体的存在;用这种受体给动物注射可诱发实验性自体免疫性重症肌无力;本病可通过被动免疫而转移.然而这种免疫性的自身的破坏(Self-destruction)似乎仅仅是一种发病机理,而其真正病因仍不清楚.在其它自身免疫性疾病中,已证实或已提出病毒性病因,某些作者主张MG的病因包括病毒的可能性.
Myasthenia gravis (MG) is a disease of unknown etiology whose pathogenesis is an autoimmune response to the acetylcholine receptor (AchR) at the neuromuscular junction. The confirmation of this mechanism is based on the fact that MG patients are present Humoral antibodies, and confirmation of AchR-specific cell-mediated immune responses; the presence of antibodies at neuromuscular junctions; injection of this receptor into animals induces experimental autoimmune myasthenia gravis; the disease can be transferred by passive immunization However, this self-destruction of immunity appears to be a mere pathogenesis whose true etiology is still unclear.Among other autoimmune diseases, viral etiologies have been demonstrated or have been proposed, and some The authors argue that the cause of MG includes the possibility of a virus.