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目的结合DTI探讨Isoket在DSE中对左室舒张功能的影响。方法25例研究对象均经QCA证实为冠心病患者,随机分为两组:CAD1组(15例,行标准DSE检查)和CAD2组(10例,行Isoket+标准DSE检查),两组间患者的冠脉病变程度无显著性差异;所有患者均使用DTI技术,分别于静息状态、Dobu小剂量(10μg/Kg.min)及峰值剂量时观察左室16个节段心肌运动速度的变化,记录各室壁节段的收缩期(S)、舒张早期(E)及舒张晚期(A)的峰值速度Vs、Ve及Va,用t检验检测两组间各测值的差异性。结果以Vs及Ve的双相反应作为判断存活心肌标准;当峰值剂量Dobu输注时,CAD2组的Va值明显高于CAD1组,二者差异显著;即峰值剂量Dobu时CAD2组左室舒张功能较CAD1组明显恶化。结论Isoket不仅可以协同Dobu使存活心肌产生双相反应,其对存活心肌舒张功能的影响更具有研究的潜在价值。
Objective To investigate the effect of Isoket on left ventricular diastolic function in DSE combined with DTI. Methods Twenty-five patients with coronary heart disease (QCA) were randomly divided into two groups: CAD1 group (n = 15), CAD2 group (n = 10) and patients with Isoket + standard DSE All the patients underwent DTI technique to observe the change of myocardial velocity in 16 segments of left ventricle at rest, Dobu low dose (10μg / Kg.min) and peak dose The systolic (S), peak diastolic (Vs), Ve and Va of early diastolic (E) and late diastolic (A) segments of the wall segment were measured by t test to test the differences between the two groups. Results Two-phase response of Vs and Ve was used as a criterion for determining viable myocardium. When Dobu was infused at peak dose, the value of Va in CAD2 group was significantly higher than that in CAD1 group. There was significant difference between the two groups. That is, left ventricular diastolic function Significantly worse than the CAD1 group. Conclusions Isoket can not only produce biphasic response to viable myocardium in combination with Dobu, but also have potential value for studying the effect of diastolic function on viable myocardium.