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目的探讨肿瘤坏死因子（TNF）与肝损伤的关系。方法测定NS例肝炎患者的TNF浓度及肝功能，同时以30名健康献血员作对照组，结果以t检验作统计学分抓结果各组肝病患者血清TNF水平较正常对照组（0.74±0.15ng·ml-1）显著升高（P＜0.01），以重症肝炎（1.58±0.67ng·ml-1）并高最显著（P＜0.001）。结论TNF在重症肝炎发病中起重要作用，是参与肝损伤及坏死的重要介质因子。
Objective To investigate the relationship between tumor necrosis factor (TNF) and liver injury. Methods TNF levels and liver function were measured in patients with NS hepatitis and 30 healthy blood donors were used as control group. The results were analyzed by t test. Results The levels of serum TNF in patients with liver disease were significantly higher than those in normal controls (0.74 ± 0.15 ng · Ml-1) (P <0.01), with severe hepatitis (1.58 ± 0.67ng · ml-1) and the most significant (P <0.001). Conclusion TNF plays an important role in the pathogenesis of severe hepatitis and is an important mediator involved in liver injury and necrosis.