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我院门诊药房,发现分装的氨茶硷片,经过几个小时,药片的两个平面就变为深黄色。作为劣药处理。原因如何?经调查、实验,证明是分装过维生素的用具,未擦洗干净,又用来分装氨茶硷片,这样就使氨茶硷片表面粘附了少量维生素 C,而氨茶硷为茶硷和乙二胺的复盐,遇酸性物质(如维生素 C、CO_2等),即被分解为茶硷和乙二胺;变色的原因,可能是茶硷被空气氧化所引起。
Outpatient pharmacy in our hospital, found that sub-sub-aminophylline tablets, after a few hours, the two tablets into a dark yellow plane. As a poor treatment. The reason? After investigation, experiment, proved to be the equipment of vitamins dispensing, not scrub clean, but also for the sub-aminophylline tablets, so that the surface of ammonia tea tablets attached to a small amount of vitamin C, and theophylline The complex salt of theophylline and ethylenediamine, acidic substances (such as vitamin C, CO_2, etc.), that is, is decomposed into theophylline and ethylenediamine; discoloration may be theophylline caused by air oxidation.