目的:探讨体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)周期中,超短方案在卵巢低反应患者(poor ovarian responders,PORs)中的应用。方法:回顾性分析342例PORs的401个IVF周期,根据促排卵方案不同分为超短方案组(A组,254例,291个周期)和微刺激方案组(B组,88例,110个周期)。比较A、B组的一般资料、妊娠结局以及周期取消率等指标,分析A、B组周期取消原因。结果:临床妊娠率/移植周期、种植率和流产率组间均无统计学差异(P>0.05),但A组累积妊娠率显著高于B组(25.1%vs 14.5%,P<0.05),周期取消率显著低于B组(17.5%vs 44.5%,P<0.05)。周期取消原因分析表明,微刺激组因内膜因素取消移植的比例显著高于超短方案组(22.4%vs 7.8%,P<0.05)。结论:在PORs中,超短方案周期取消率低,患者心理压力小,整个疗程耗时短。因此超短方案也是PORs可以选择的、较理想的促排卵方案。 Objective: To investigate the application of ultrashort protocol in poor ovarian responders (PORs) during in vitro fertilization-embryo transfer (IVF-ET). Methods: 401 IVF cycles of 342 PORs were retrospectively analyzed. According to the ovulation induction schedule, they were divided into two groups: ultrashort plan group (A group, 254 cases, 291 cycles) and micro stimulation group (B group, 88 cases, 110 cases cycle). A group B general information, pregnancy outcomes and cycle cancellation rate and other indicators, analysis of A, B group cancellation reasons. Results: The cumulative pregnancy rates in group A were significantly higher than those in group B (25.1% vs 14.5%, P <0.05), but no significant difference was found between clinical pregnancy rate / transplantation cycle, implantation rate and abortion rate (P> 0.05) Cycle cancellation rate was significantly lower than the B group (17.5% vs 44.5%, P <0.05). Analysis of the reasons for the cancellation of cycles showed that the rate of canceration of endometrium was significantly higher in the micro-stimulated group than in the short-term group (22.4% vs 7.8%, P <0.05). Conclusion: In the PORs, the ultra-short program cycle cancellation rate is low, patients with small psychological stress, the entire course of treatment time-consuming. Therefore, the ultra-short program is PORs can choose the ideal ovulation program.