论文部分内容阅读
Uteroglobin(UG)是一种由类固醇类激素诱导分泌 ,进化上高度保守 ,具有免疫调节及抗炎等多种生物学功能的蛋白。它组织分布十分广泛 ,在外周血和尿中均可被检出。人的UG基因定位在染色体 11q12 .3～13.1,UG基因敲除的小鼠和UG反义转基因小鼠都表现出明显的肾脏损害 ,特别是IgA肾病的临床和病理特征。本文就UG的结构特点、生物学功能及其在肾脏病研究领域 ,特别是对于IgA肾病的机制研究方面的进展进行综述。
Uteroglobin (UG) is a protein that is secreted by steroid hormones, highly conserved in evolution, and has many biological functions such as immunomodulation and anti-inflammatory. Its tissue distribution is very wide, in the blood and urine can be detected. Human UG gene locates on chromosomes 11q12.3-1.3.1, UG knockout mice and UG antisense transgenic mice both show obvious renal damage, especially clinical and pathological features of IgA nephropathy. This review summarizes the structural features, biological functions of UG and its progress in the research of kidney disease, especially the mechanism of IgA nephropathy.