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目的:探讨急性脑梗死合并2型糖尿病患者大血小板比率(large platelets,P-LCR)和平均血小板体积(mean platelet volume,MPV)的变化及临床意义。方法:选取2012年1月至2015年3月在我院住院的急性脑梗死患者627例,分成伴2型糖尿病的急性脑梗死组(225例)和不伴2型糖尿病的急性脑梗死组(402例),采用全自动血液分析仪检测P-LCR和MPV水平,并进行比较分析。结果 :与不伴2型糖尿病的急性脑梗死组患者比较,伴2型糖尿病的急性脑梗死组患者的P-LCR增加及MPV增大,两组间差异均有统计学意义(P<0.05)。Logistic回归分析发现高血压、高血脂和P-LCR为急性脑梗死合并2型糖尿病患者的高危因素(P<0.05)。结论:P-LCR和MPV的水平可作为急性脑梗死合并2型糖尿病患者病情预测和早期诊治的重要参考指标。
Objective: To investigate the changes and clinical significance of large platelets (P-LCR) and mean platelet volume (MPV) in patients with acute cerebral infarction complicated with type 2 diabetes mellitus. Methods: A total of 627 acute cerebral infarction patients admitted to our hospital from January 2012 to March 2015 were divided into two groups: acute cerebral infarction with type 2 diabetes (225 cases) and acute cerebral infarction without type 2 diabetes 402 cases). The levels of P-LCR and MPV were detected by automatic hematology analyzer and analyzed comparatively. Results: Compared with patients without acute cerebral infarction without type 2 diabetes, P-LCR increased and MPV increased in patients with acute cerebral infarction with type 2 diabetes mellitus, the differences were statistically significant (P <0.05) . Logistic regression analysis found that hypertension, hyperlipidemia and P-LCR were risk factors for acute cerebral infarction with type 2 diabetes (P <0.05). Conclusion: The levels of P-LCR and MPV can be used as important reference indicators for the prognosis and early diagnosis and treatment of type 2 diabetes mellitus in patients with acute cerebral infarction.