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①目的观察早期干预对防治缺氧缺血性脑病（ＨＩＥ）病儿脑功能障碍的效果。②方法将５７例ＨＩＥ病儿随机分为干预组（２９例）和对照组（２８例）。干预组自新生儿期开始接受早期干预。两组均于１．５岁、２．０岁按双盲法进行Ｂａｙｌｅｙ婴幼儿智能发育量表测试。③结果干预组在１．５岁时Ｂａｙｌｅｙ测试精神发育指数（ＭＤＩ）较对照组高１３．２分，两组比较差异均有极显著意义（ｔ＝３．２９，Ｐ＜０．０１），运动发育指数（ＰＤＩ）高８．７分，两组比较差异有显著性（ｔ＝２．３２，Ｐ＜０．０５）；２岁时ＭＤＩ较对照组高１４．２分，ＰＤＩ高９．３分，两组比较差异均有极显著性（ｔ＝３．２７，２．７９，Ｐ均＜０．０１）。④结论早期干预对防治ＨＩＥ病儿脑功能障碍有显著效果。
Objective To observe the effect of early intervention on brain dysfunction in children with hypoxic-ischemic encephalopathy (HIE). Methods 57 children with HIE were randomly divided into intervention group (n = 29) and control group (n = 28). The intervention group received early intervention from the neonatal period. Both groups were 1.5 years old, 2.0 years old by double-blind method Bayley infant intelligent developmental scale test. Results The Bayley test mental development index (MDI) of the intervention group was 13.2 points higher than that of the control group at the age of 1.5. There was significant difference between the two groups (t = 3.29, P <0.01) The PDI was 8.7 points higher, with significant difference between the two groups (t = 2.32, P <0.05). At 2 years, the MDI was 14.2 points higher than the control group and the PDI was 9. 3 points, the difference between the two groups was significant (t = 3.27,2.79, P <0.01). ④ Conclusion Early intervention in prevention and treatment of HIE children brain dysfunction have a significant effect.