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自由基(FR)是指含有不配对(奇数)电子的原子、分子或基团。人们对FR的认识已有数十年的历史,但直至近几年,对FR的生物学意义尤其是FR在组织损伤中的作用才有比较明确的认识。氧FR是组织内氧的异常代谢副产物。肾脏组织中最早生成的氧FR主要是O_2~-、OH与H_2O_2(H_2O_2实际上不是FR,因它与OH~(?)的生成有直接关系故一起讨论)。肾脏是对缺血以及再灌流损伤非常敏感的器官,肾脏缺血对肾组织的损伤作用及其在急性肾功
Free radical (FR) refers to an atom, molecule or group containing unpaired (odd) electrons. People’s understanding of FR has been decades, but until recently, there was a clear understanding of the biological significance of FR, especially the role of FR in tissue damage. Oxygen FR is an aberrant metabolic by-product of oxygen in tissues. The earliest generation of oxygen FR in kidney tissues is mainly O_2 ~ -, OH and H_2O_2 (H_2O_2 is actually not FR, because it is directly related to the formation of OH ~ (?) Are discussed together. Kidneys are organs that are very sensitive to ischemia and reperfusion injury, renal damage caused by renal ischemia and their role in acute renal function