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目的：比较二种铂类药物治疗鼻咽癌（ＮＰＣ）的临床疗效和毒副作用。方法：３４例有颈淋巴结转移的ＮＰＣ患者分两组（各１７例）进行放疗前化疗。两组化疗第１～５ｄ（ｄ１～５）均给以５－Ｆｕ１０００ｍｇ／ｍ２静滴（ｉｖｄｒｏｐ）外，第１ｄ（ｄ１）Ａ组卡铂（ＣＢＰ）３００ｍｇ／ｍ２ｉｖｄｒｏｐ；Ｂ组顺铂（ＤＤＰ）１００ｍｇ／ｍ２ｉｖｄｒｏｐ。结果：ＯＲ（ＣＲ＋ＰＲ）：Ａ组５２．９４％，Ｂ组６４．７１％，Ｐ＞０．０５，差异无显著性；两组ＷＢＣ值第３周最低，第４周回升，且Ａ组第２～３周ＷＢＣ均值比Ｂ组低，按ＷＨＯ毒性与分级标准ＷＢＣ降至Ⅲ－Ⅳ级Ａ组４７．０６％，Ｂ组１１．８２％，Ｐ＞０．０５，差异有显著性。结论：ＣＢＰ＋５－Ｆｕ与ＤＤＰ＋５－Ｆｕ治疗ＮＰＣ疗效相近，ＣＢＰ不需水化，可在门诊执行，两组ＷＢＣ均值都在第３周最低，第４周恢复，但ＣＢＰ对ＷＢＣ的影响要较ＤＤＰ严重
Objective: To compare the clinical efficacy and side effects of two platinum drugs in the treatment of nasopharyngeal carcinoma (NPC). Methods: Thirty-four NPC patients with cervical lymph node metastasis were divided into two groups (17 in each group) for pre-radiotherapy chemotherapy. Patients in both groups received intravenous infusion of 5-Fu 1000 mg / m2 iv on day 1 to 5 d (d1 to 5), 300 mg / m2 iv drop on day 1 d (d1), and group B received cisplatin 100mg / m2ivdrop. Results: OR (CR + PR): A group of 52.94%, B group 64.71%, P> 0.05, the difference was not significant; WBC values were lowest in the third week, the fourth week rose, WBC mean was lower than that of group B in 2 ~ 3 weeks, and it was 47.06% in group Ⅲ-Ⅳ and 11.82% in group B according to the WHO WBC classification criteria WBC, P> 0.05, the difference was significant. CONCLUSION: CBP + 5-Fu and DDP + 5-Fu have similar curative effect on NPC, while CBP does not require hydration and can be performed in outpatient setting. The WBC mean of the two groups is the lowest in the third week and restored in the fourth week, but the impact of CBP on WBC is more than that of DDP serious