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原发性纤维蛋白溶解症(primary fibrinolysis)又称原发性纤溶,是由于纤溶系统活性异常增强,导致纤维蛋白过早、过度破坏和(或)纤维蛋白原等凝血因子大量降解,并引起出血,是纤维蛋白溶解亢进(纤溶亢进)的一个类型。原发性纤溶发生在无异常凝血的情况下,又可分为先天性(如:α2抗纤溶酶缺乏、纤溶酶原活化抑制物-1缺乏、纤溶酶原活化物增多)和获得性(如:严重肝脏疾病、肿瘤、手术和创伤、溶栓治疗)2种,以后者居多。
Primary fibrinolysis, also known as primary fibrinolysis, is due to an abnormally increased fibrinolytic system activity leading to premature, excessive destruction of fibrin and / or massive degradation of coagulation factors such as fibrinogen, and Bleeding is a type of hypertrophy (fibrinolysis). Primary fibrinolysis occurs in the absence of abnormal coagulation, and can be divided into congenital (such as: α2 anti-plasmin deficiency, plasminogen activator inhibitor-1 deficiency, plasminogen activator increased) and Acquired (such as: severe liver disease, cancer, surgery and trauma, thrombolytic therapy) 2, the latter majority.