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目的 阐明MUC 1在胎儿胃黏膜的表达特点 ,探讨MUC 1与胃上皮分化的关系。 方法 应用HE染色和SP免疫组织化学方法 ,检测 2 2例 9～ 30周胎儿胃黏膜的发育以及MUC 1在不同时期的表达。 结果 胎儿胃黏膜的分化可分为 3个不同时期 :1 在未分化期MUC 1呈极性分布于早期胃上皮的游离面。 2 在分化期MUC 1呈极性和弥漫性分布于中期胃黏膜上皮和腺上皮。 3 生长期MUC 1分布于胃底腺上皮。 结论 MUC 1的表达与胃上皮的分化密切相关。
Objective To clarify the expression of MUC 1 in fetal gastric mucosa and to explore the relationship between MUC 1 and gastric epithelial differentiation. Methods HE staining and SP immunohistochemistry were used to detect the gastric mucosal development and the expression of MUC 1 in 22 fetuses from 9 to 30 weeks. Results Fetal gastric mucosal differentiation can be divided into three different stages: 1 in the undifferentiated MUC 1 showed a polar distribution in the early gastric epithelium free surface. 2 MUC 1 was polarized and diffusely distributed in metaphase gastric mucosa epithelium and glandular epithelium during differentiation. 3 growth stage MUC 1 distribution in the fundus glandular epithelium. Conclusion MUC 1 expression is closely related to the differentiation of gastric epithelium.