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目的：探讨阿尔茨海默病（AD）患者的生存质量、照料者负担及相关影响因素。方法该研究为横断面研究，选择该院神经内科确诊的84例 AD 患者及其照料者，采用 AD 患者生存质量量表（QOL‐AD）评估患者的生存质量，使用照料者负担量表（CBI）、家庭负担量表（FBS）评价 AD 患者照料者的负担。患者生存质量、照料者家庭负担总分与患者因素的相关关系采用Pearson 相关分析，采用多元线性回归模型分析影响患者生存质量和照料者负担的相关影响因素。结果 AD 患者生存质量QOL‐AD 总分为（30．7±4．8）分，各因子评分由高到低依次为：精力、家庭关系、情绪、对自己的整体感觉、身体健康状况、生活整体情况、进行娱乐能力、经济状况、居住环境、做家务能力、朋友关系、婚姻状况、记忆力。照料者负担 CBI 总分为（53．4±17．3）分，各因子排序依次为：发展受限负担、身体性负担、情感性负担、时间依赖负担、社会性负担。家庭负担 FBS 总分为（17．2±9．8）分，各因子排序依次为：家庭日常活动、家庭经济负担、家庭娱乐活动、家庭关系、家庭成员躯体健康和家庭成员心理健康，其中除家庭成员躯体健康和心理健康外均为中度负担。 AD 患者生存质量与照料者负担（ r ＝－0．232，P ＝0．013）及照料者家庭负担（r＝－0．229，P＝0．005）之间均呈负相关关系。多因素分析显示，对照料者负担 CBI 总分有影响的因素（按影响程度排序）有痴呆程度、日常生活能力、生存质量；对照料者家庭负担 FBS 总分有影响的因素（按影响程度排序）有生存质量和痴呆程度。结论 AD患者的生存质量普遍偏低、AD 患者的痴呆程度、日常生活能力和生存质量照料者及家庭负担的影响较大。“,”Objective To explore the influencing factors of quality of life and family burden in patients with Alzheimer′s disease . Methods This study is a cross‐sectional study ,84 AD patients and their caregivers were selected from People′s Hospital of Chang‐shou Chongqing as the research object .Their qualities of life were evaluated by Quality of Life‐Alzheimer′s Disease(QOL‐AD) , Family Burden were evaluated by Caregiver Burden Inventory (CBI) and the Family Burden Scale(FBS) .The analysis of variance and t test were applied in comparing the intergroup difference of measurement data .Pearson correlation analysis were applied in comparing the relationship between the quality of life score ,family caregiver burden score and the patient factors .Multiple linear re‐gression model were applied to analyze the factors affecting the quality of life of patients and caregiver burden .Results AD patients quality of life scores for(30 .8 ± 4 .8) ,each factor score from high to low in order for :energy ,family relationships ,emotion ,on their overall feeling ,physical health status ,life of overall situation ,entertainment and ability ,economic status ,living environment ,do the housework ability ,friend relationship ,marital status and memory .Total score of CBI for(53 .4 ± 17 .3) ,caregiver burden factor or‐der as follows :development limited burden ,body burden ,emotional burden ,time dependent burden and social burden .FBS score for (17 .2 ± 9 .8) ,family burden factor order as follows :the daily family activity ,family economic burden ,family entertainment ,family relationship ,family members of the body health and mental health of family members ,which in addition to the family members of physical health and mental health were moderate burden .Between AD patients quality of life and the burden of caregivers (r= - 0 .232 ,P= 0 .013) and family burden of the caregivers (r = - 0 .229 ,P= 0 .005) showed a negative correlation .Multivariate analysis showed that :(according to the influence degree of order ) with the degree of dementia ,ability of daily living and quality of life ;have an influence on the total score of family burden of the caregivers of FBS factors (according to the influence degree of order ) quality of life and the dementia process of factors impact on caregiver burden CBI scores .Conclusion The quality of life of patients with AD is generally low ,ability the effects of AD patients with the degree of dementiaof daily living and quality of life caregivers and family burden greatly .