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十二指肠粘膜下Brunner 腺具有分泌碱性粘稠液体的能力,因此而能保护十二指肠粘膜免受胃酸侵袭。因此认为,Brunner 腺是十二指肠粘膜防御因子之一。可以设想,胃酸分泌亢进的十二指肠溃疡患者常可发生Brunner 腺某些形态和功能变化,为此,作者对十二指肠溃疡患者测定了Brunner 腺厚度,以研究Bru-nner 腺在十二指肠溃疡发病中的病理生理学意义。作者收集因穿孔、出血、狭窄而施行外科切除的75例十二指肠溃疡标本。以溃疡病变为中心沿十二指肠纵轴方向切开,标本经百腊包埋,制成4～6μm 组织切片,进行HE 和PAS 染色。然后用眼状测微计测
The duodenal submucosal Brunner gland has the ability to secrete an alkaline viscous fluid and thus protect the duodenal mucosa from gastric acid attacks. Therefore, it is considered that Brunner gland is one of the defensive factors of duodenal mucosa. It is conceivable that patients with duodenal ulcer with hyperacidity often have some morphological and functional changes in Brunner’s glands. For this reason, the authors determined Brunner’s gland thickness in patients with duodenal ulcer to study Brunnner’s glands in ten. Pathophysiological significance in the pathogenesis of duodenal ulcer. The authors collected 75 duodenal ulcer specimens that were surgically resected for perforation, bleeding, and stenosis. The lesion was centered along the longitudinal direction of the duodenum and the specimen was embedded in 100-wax tissue to make 4-6 μm tissue sections for HE and PAS staining. Then using an eye micrometer