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目的 探讨肝硬化患者血清胰岛素样生长因子 I(IGF I)测值改变及其与肝功能Child分级间的关系。方法 45例肝炎后肝硬化患者及 34例健康对照者应用免疫放射法测定血清IGF I值 ,比较IGF I在正常人与肝硬化以及肝功能不同Child级别组中的变化。结果 肝硬化患者的血清IGF I值 (2 45 .5 3± 94.0 9)ng/ml明显低于正常组 (6 7.98± 6 5 .97)ng/ml,P <0 .0 0 1,且随肝功能Child分级的增高而进行性下降。 结论 IGF I测值与肝功能状况有明显的相关性 ,测值低于 30ng/ml则临床预后不良。研究结果提示血清IGF I测定是一项重要的肝功能状况评估的检测指标
Objective To investigate the change of serum insulin-like growth factor I (IGF-I) in patients with cirrhosis and its relationship with Child grading of liver function. Methods Forty-five patients with posthepatitic cirrhosis and 34 healthy controls were enrolled in this study. Serum IGF-I levels were measured by immuno-radioimmunoassay and the changes of IGF-I levels were compared between normal and cirrhosis patients and in Child-level group with different liver function. Results Serum IGF I levels in patients with cirrhosis were significantly lower than those in the normal group (24.98 ± 6.55.97 ng / ml, P <0.001) Liver function Child grade increased and progressive decline. Conclusion There is a significant correlation between IGF I measurement and liver function status. If the measurement is below 30ng / ml, the clinical prognosis is poor. The results suggest that serum IGF-I measurement is an important indicator of assessment of liver function