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试验研究了中药壮阳促孕散对雌性肾阳虚大鼠垂体—性腺轴分泌激素的影响,初步探讨其作用机制。用氢化可的松造雌性大鼠肾阳虚模型,造模21 d,从试验第八天开始,中药治疗组灌胃中药壮阳促孕散,阳性对照组灌胃金匮肾气丸,连续给药14 d。放射免疫法测定血清中雌二醇(E2)、孕酮(P)、黄体生成素(LH)和促卵泡激素(FSH)。结果表明,模型对照组造模后大鼠出现明显的阳虚症状,体重下降,血清中E2、P下降,LH、FSH升高,给药后阳性对照组、中药治疗组大鼠体重增加,血清中E2、P升高,LH、FSH下降。中药壮阳促孕散可调节雌性肾阳虚大鼠血清中LH、FSH、E2和P的分泌,对生殖内分泌有促进作用。
The effects of Zhuang Yang Prescription for Pregnancy on the secretion of hormones in the pituitary gonad axis of female rats with deficiency of kidney-yang were studied and the mechanism of action was preliminarily explored. Hydrocortisone female rat model of kidney yang, modeling 21 d, starting from the eighth day of the experiment, the traditional Chinese medicine group was given intragastric administration of aphrodisiac and masturbation, the positive control group was given Jinguishenqi Pill continuously Medicine 14 d. Serum estradiol (E2), progesterone (P), luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured by radioimmunoassay. The results showed that the rats in the model control group showed obvious signs of yang deficiency, weight loss, decreased serum E2, P and elevated LH and FSH. After the administration, the rats in the positive control group and the traditional Chinese medicine treatment group gained weight, serum In E2, P increased, LH, FSH decreased. The traditional Chinese medicine Zhuangyang Prescription for Tonifying Powder can regulate the secretion of LH, FSH, E2 and P in the serum of female rats with deficiency of yang and promote the reproductive and endocrine effects.