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目的利用血氧水平依赖性功能性磁共振成像(BOLD-fMR I)技术,探索人类近视性屈光参差是否对大脑皮层功能和结构造成影响。方法采用无磁MR I专用眼镜纠正屈光不正,以1.5T磁共振成像系统采集8例近视性屈光参差者枕叶视皮层兴趣区BOLD-fMR I数据,比较双眼皮层激活部位及范围的不同,及视力较差眼屈光纠正前后皮层激活情况的变化,分析其改变特点及机制。结果矫正屈光基础上,近视性屈光参差者双眼激活范围没有明显差异(P>0.05);视力较差眼屈光矫正前后皮层激活范围有明显差异(P<0.05)。结论人类近视性屈光参差可能没有发生明显的皮层功能损害及优势眼的转移;配镜可明显提高视力较差眼的皮层激活,应尽早配镜或手术矫正。
Objective To explore whether human myopia anisometropia can affect the function and structure of the cerebral cortex by using BOLD-fMRI (SpO2-dependent Magnetic Resonance Imaging) technique. Methods Non-magnetic MR I glasses were used to correct refractive errors. BOLD-fMR I data of 8 eyes with myopic anisometropia were collected by 1.5T magnetic resonance imaging system. Different, and poor eyesight refractive correction before and after cortical activation changes, analysis of its changing characteristics and mechanisms. Results On the basis of refractive correction, there was no significant difference in the extent of activation of both eyes in myopic anisometropia (P> 0.05). There was a significant difference in the activation of cortex before and after refractive correction (P <0.05). Conclusion Myopic anisometropia may not occur significant cortical dysfunction and dominant eye metastasis; glasses can significantly improve the poor eyesight cortical activation, glasses or surgery should be corrected as soon as possible.