迄今未见甲硝唑血清和唾液浓度相关问题的报道,作者对此作了初步探讨,简报如下。 6名健康志愿受试者,20—28岁,晨空腹口服甲硝唑片0.4g,於24小时内不同时间抽血并留取唾液。血清加入5％高氯酸溶液沉淀蛋白后离心取上清液分析。用情水漱口后,含入少量枸椽酸结晶刺激唾液分泌,弃 So far no reports of metronidazole serum and saliva concentration related issues, the authors made a preliminary discussion, the briefing is as follows. Six healthy volunteers, 20-28 years old, morning fasting oral metronidazole tablets 0.4g, at different times within 24 hours to take blood and saliva. Serum was added to 5% perchloric acid solution to precipitate the protein and centrifuged to analyze the supernatant. Mouthwash with water, containing a small amount of citric acid crystals stimulate salivation, discard