肾上腺皮质类固醇,自1948年应用于治疗类风湿性关节炎以来已历廾余年,现普遍应用于临床各科。为了合理地使用它,避免或减少其不良后果,今就其临床应用中的几个问题试谈如下。一、对垂体——肾上腺功能调节的认识肾上腺皮质分泌功能,受垂体前叶分泌的促皮质素(ACTH)所调节。ACTH的释放则受下丘脑管辖的促皮质素释放因子(CRF)所控制。下丘脑——垂体——肾上腺的功能活动,在正常情况下相互调 Adrenal corticosteroids, which have been used in the treatment of rheumatoid arthritis since 1948 for more than a year, are now commonly used in clinical settings. In order to use it reasonably and to avoid or reduce its adverse consequences, several questions in clinical application are discussed below. First, the understanding of the regulation of pituitary-adrenal function adrenal secretion, by the anterior pituitary secretion of corticotropin (ACTH) regulation. ACTH release is regulated by the hypothalamic corticotropin releasing factor (CRF). Hypothalamic - pituitary - adrenal functional activity, under normal circumstances, mutual adjustment