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CD44在淋巴细胞激活中起重要作用,在激活信号的传递过程中,CD44与 CD2、CD3、LFA 等有密切关系,由 CD44介导的信号传导可引起胞内 Ca~(2+)/cAMP 的升高及 p56~(lck)、pp125~(FAk)发生蛋白酪氨酸磷酸化。
CD44 plays an important role in the activation of lymphocytes. CD44 is closely related to CD2, CD3, LFA and so on. CD44-mediated signal transduction leads to intracellular Ca2 + / cAMP Elevated and p56 ~ (lck), pp125 ~ (FAk) protein tyrosine phosphorylation.