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目的 探讨肟类药物氯解磷定 (PAM Cl)和 (吡啶 2 醛肟 1 1 甲基 ) (4 氨基甲酰基 吡啶 1 甲基 )醚氯盐 (HI 6 )对甲基对硫磷与灭多威杀虫剂混配中毒动物的保护作用 ,并比较肟类、阿托品 (At)及At与肟类联合应用的疗效。方法 小鼠和大鼠灌胃染毒后 ,经腹腔注射生理盐水、肟类、At及At与肟类药物 ,记录各组动物的中毒表现和死亡结局 ,并测定血和脑中胆碱酯酶 (ChE)活力。结果 各治疗组和对照组相比 ,中毒表现均有一定程度的减轻 ,尤以At与肟类联合应用疗效为著。各治疗组的存活率 (小鼠分别为 :PAM Cl 90 %、HI 6 90 %、At 90 %～ 10 0 %、PAM Cl +At 10 0 %、HI 6 +At 90 % ;大鼠分别为 :PAM Cl 6 0 %、At 10 0 %、PAM Cl +At 10 0 % )与对照组 (小鼠 :40 %～6 0 % ;大鼠 :6 0 % )相比 ,除PAM Cl组外 ,存活率均显著提高 ,差异有显著性 ,P <0 .0 5 (小鼠 :PAM Cl组 ,P =0 .15 2 ;At组 ,P =0 .0 2 9～ 0 .0 43;PAM Cl+At组 ,P =0 .0 43;HI 6组 ,P =0 .0 2 9;HI 6 +At组 ,P =0 .0 2 9。大鼠 :PAM Cl组 ,P =1.0 0 0 ;At组 ,P =0 .0 43;PAM Cl+At组 ,P =0 .0 43)。PAM Cl对受抑制的全血ChE有一定的重活化作用。结论 急性甲基对硫磷与灭多威杀虫剂混配中毒时 ,肟类可作为At的辅助治疗药物。
Objective To investigate the effects of oxime drugs such as chlorpyrifos (PAM Cl) and (pyridine 2 aldoxime 1 1 methyl) (4 carbamoylpyridine 1 methyl) ether chloride (HI 6) Wei insecticides mixed poisoned animal protection, and compare the efficacy of oximes, atropine (At) and At combination with oximes. Methods After intragastric administration, mice and rats were injected intraperitoneally with normal saline, oximes, At and At and oximes, and the poisoning performance and death outcome of each group of animals were recorded. The blood and brain cholinesterase (ChE) vitality. Results Compared with the control group, the poisoning performance of each treatment group was relieved to some extent, especially the combination of At and oxime. The survival rate of each treatment group (mice: PAM Cl 90%, HI 6 90%, At 90% ~ 100%, PAM Cl + At 10 0%, HI 6 + At 90%; rats were: PAM Cl 6 0%, At 10 0%, PAM Cl + At 10 0%) survived compared to the control group (mice: 40% -60%; rat: 60% P <0.05 (mice: PAM Cl group, P = 0.15 2; At group, P = 0.022-9.0403; PAM Cl + At group, P = 0.043; HI 6 group, P = 0.029; HI 6 + At group, P = .0 2 9. Rats: PAM Cl group, P = 1.0 0 0; At Group, P = 0 .0 43; PAM Cl + At group, P = .0 43). PAM Cl inhibits the repression of whole blood ChE have a certain degree of reactivation. Conclusion When acute methyl parathion mixed with methomyl insecticide poisoning, oximes can be used as adjuvant treatment of At.