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采用细胞外电极引导动作电位方法,观察了4种浓度复方盐酸普鲁卡因,普鲁卡因和利多卡因对蟾蜍离体坐骨神经复合动作电位幅度的影响。结果表明:4种不同浓度复方盐酸普鲁卡因,普鲁卡因和利多卡因均可降低复合动作电位的幅度,呈剂效反应关系。其中1.9％复方盐酸普鲁卡因与同浓度普鲁卡因或利多卡因相比,前者可显著增加复合动作电位的衰减率,并呈时间反应关系(2分钟P<0.05,3～8分钟P<0.01)。复合动作电位完全消失的时间为8分钟,这一时间明显快于同浓度普鲁卡因和利多卡因。提示:1.9％的复方盐酸普鲁卡因可显著抑制复合动作电位的形成,神经阻断作用强于普鲁卡因或利多卡因单独使用。
The effect of four concentrations of compound procaine hydrochloride, procaine and lidocaine on the amplitude of combined action potentials of isolated sciatic nerve in toads was observed by using the method of extracellular lead-induced action potential. The results showed that the four different concentrations of compound procaine hydrochloride, procaine and lidocaine can reduce the magnitude of compound action potential, showed a dose-response relationship. Among them, 1.9% compound procaine hydrochloride could significantly increase the compound action potential decay rate compared with the same concentration of procaine or lidocaine (P <0.05 for 2 min, 3 to 8 min P <0.01). Compound action potential disappeared completely for 8 minutes, this time was significantly faster than the same concentration of procaine and lidocaine. Hint: 1.9% procaine hydrochloride compound can significantly inhibit the formation of compound action potential, and the effect of nerve blockade is better than that of procaine or lidocaine alone.