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采用中心波长为840 nm,带宽为50 nm的宽带近红外光源,基于低相干干涉原理和快速扫描延迟线(RSOD)相位调制的外差探测方法,建立了单模光纤型光学相干层析(OCT)成像系统,依此获得自然状态下活体组织的二维纵向截面成像图像。实验结果表明,系统的轴向分辨率为6.7μm,接近理论分辨率,纵向成像范围高达3 mm,横向分辨率为4.7μm;入射到样品的光功率低于300μW,系统探测灵敏度大于88 dB。在保证样品入射光功率相同的情况下,与中心波长为1310 nm,带宽为65 nm的单模光纤型光学相干层析成像系统对含水量高的新鲜橙子果肉的成像结果进行对比,验证了该系统用于眼后段组织成像的优越性,给出了活体动物视网膜的成像结果。
The broadband near-infrared light source with a center wavelength of 840 nm and a bandwidth of 50 nm was used to establish a single-mode optical fiber optical coherence tomography (OCT) based on the heterodyne detection method of low coherence interference and fast scan delay line (RSOD) phase modulation ) Imaging system, thus obtaining the natural state of living tissue two-dimensional longitudinal section imaging images. The experimental results show that the axial resolution of the system is 6.7μm, which is close to the theoretical resolution. The longitudinal imaging range is up to 3 mm and the horizontal resolution is 4.7μm. The optical power incident on the sample is less than 300μW and the system detection sensitivity is greater than 88 dB. Compared with the imaging results of fresh orange pulp with high water content, the single-mode optical fiber optical coherence tomography system with central wavelength of 1310 nm and bandwidth of 65 nm ensures that the incident light power of the sample is the same, The superiority of the system for tissue imaging in the posterior segment of the eye gives the imaging results of the living animal retina.