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串联反应具有原料简单易得、中间产物无需分离提纯、操作简单、节省溶剂和降低消耗等很多独特优点,已成为当前有机合成研究的热点课题.缺电子炔烃与芳香胺在温和条件下快速反应生成的β-烯胺酯,具有丰富的化学反应性质,可以作为多组分串联反应的关键中间体,和其它组分进行串联反应,构建结构复杂的碳链、碳环、杂环化合物和螺环化合物.综述了近年来此类直接生成的β-烯胺酯参与的多组分串联反应的最新研究进展.
The tandem reaction has many unique advantages such as simple and easy-to-get raw materials, simple and convenient separation of intermediate products, simple operation, solvent conservation and consumption reduction, and has become a hot topic in the field of organic synthesis. The lack of alkyne and aromatic amine react rapidly under mild conditions The resulting β-enamines, with their rich chemical reactivity, can be used as key intermediates in multi-component tandem reactions to perform series reactions with other components to construct complex carbon chains, carbocycles, heterocyclic compounds and spiro compounds Recently, recent progress in the study of multi-component tandem reactions involving such directly-generated β-enamines has been reviewed.