论文部分内容阅读
本项工作研究了尼可刹米和卡地阿佐刺激猫的颈动脉体、脾臟、小赐和骨髓化学感受器对于呼吸血压的影响。(一)5％尼可刹米0.2—0.4毫升注入颈动脉竇灌注液内,就能作用于颈动脉体化学感受器产生暂短的呼吸抑制。25％的溶液0.1—0.2毫升,或出现暂短的呼吸抑制或暂停,或在抑制之后产生轻度的呼吸兴奋。卡地阿佐对于颈动脉体化学感受器的作用也相似地不明显:(二)2—5％尼可刹米或卡地阿佐0.2一O.4毫升注入脾臓灌注液内,能作用于脾臟 化学感受器产生呼吸兴奋与血压升高。1—2％的溶液0.4—0.5毫升洼入小肠灌注液内,产生与脾臟化学感受器完全相同的结果。(三)0.1—0.2％尼可刹米或卡地阿佐0.1毫升直接注入胫骨骨髓腔内,能作用于骨髓化学感受器而产生呼吸兴奋和血压升高(四)尼可刹米和卡地阿佐对于脾臟、小肠和骨髓化学感受器的作用,当向灌注液内注入适量的奴佛卡因时会被消除,待奴佛卡因的作用消失后,这些药物的作用又恢复。从上述结果得出结論,尼可刹米和卡地阿佐一样,对于颈动脉体化学感受器无明显作用。与此相反,它们却刺激脾臟、小肠和骨髓化学感受器产生反射性呼吸兴奋及血压升高。
This work investigates the effects of nicotine and cardidase on respiratory blood pressure in cats with carotid bodies, spleens, small donors and bone marrow chemosensors. (A) Injection of 0.2-0.4 ml of nicotine 5% into the carotid sinus perfusion fluid causes short-term respiratory depression in the carotid body chemoreceptor. 0.1-0.2 ml of 25% solution, or transient respiratory depression or pause, or mild respiratory irritation after suppression. Carbetazol for the role of carotid body chemoreceptors is also not obvious: (B) 2-5% Nicardoxicam or cardidazo 0.2 a 0.4 ml injection of splenic perfusion fluid, can act on the spleen chemoreceptors Produce respiratory excitement and elevated blood pressure. 0.4-0.5 ml of a 1-2% solution is allowed to enter the small intestine perfusate to produce exactly the same result as the spleen chemoreceptor. (C) 0.1-0.2% Nicotine or cardidazil 0.1 ml injected directly into the tibia medullary cavity, can act on the bone marrow chemosensor and produce respiratory excitement and elevated blood pressure (d) of Nicotian and carbidazol The role of the spleen, small intestine, and myeloid chemoreceptors is eliminated when a suitable amount of novocaine is infused into the perfusate and the effect of these drugs resumes when the effect of novocaine disappears. From the above results, it was concluded that nichemide, like that of cardidazac, had no significant effect on carotid body chemoreceptors. In contrast, they stimulate the spleen, small intestine and bone marrow chemotherapeutic receptors to produce reflexes of respiratory excitement and elevated blood pressure.