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为探讨抑癌基因ｐ１６ 、癌基因Ｃｙｃｌｉｎ Ｄ１ 和ＣＤＫ４ 在胰腺癌中的作用及其相互关系，应用免疫组织化学方法检测了ｐ１６ 、Ｃｙｃｌｉｎ Ｄ１ 和ＣＤＫ４ 基因在胰腺癌中的表达。结果：ｐ１６ 在胰腺癌中为低表达，Ｃｙｃｌｉｎ Ｄ１ 和ＣＤＫ４ 呈过度表达；ｐ１６ 与Ｃｙｃｌｉｎ Ｄ１ 呈负相关关系（ Ｐ＜ ０ ．０５） ，Ｃｙｃｌｉｎ Ｄ１ 与ＣＤＫ４ 呈正相关关系（ Ｐ＜ ０ ．０５） 。提示胰腺癌发生机理涉及ｐ１６ 、Ｃｙｃｌｉｎ Ｄ１ 和ＣＤＫ４ 基因的异常，ｐ１６ 低表达和Ｃｙｃｌｉｎ Ｄ１ 高表达在胰腺癌发生中起协同作用。
To investigate the role of tumor suppressor gene p16, oncogene Cyclin D1, and CDK4 in pancreatic cancer and their relationship, the expression of p16, Cyclin D1, and CDK4 genes in pancreatic cancer was examined by immunohistochemistry. RESULTS: p16 was low in pancreatic cancer and Cyclin D1 and CDK4 were overexpressed; p16 was negatively correlated with Cyclin D1 (P < 0. 05), and Cyclin D1 was positively correlated with CDK4 (P < 0. 05). It is suggested that the mechanism of pancreatic cancer involves the abnormalities of p16, Cyclin D1 and CDK4 genes. The low expression of p16 and the high expression of Cyclin D1 play a synergistic role in the development of pancreatic cancer.