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滤泡生发中心CD4+辅助T细胞表达CD10、PD-1、CX-CL-13、CD57、CXCR5、SAP、BCL-6和ICOS,部分T细胞淋巴瘤,如血管免疫母细胞性T细胞淋巴瘤、伴滤泡生长模式的外周T细胞淋巴瘤、原发性皮肤CD4+小至中等T细胞淋巴瘤可表达滤泡生发中心辅助T细胞的标记物,如CD10、非特殊性外周T细胞淋巴瘤和间变性大细胞淋巴瘤也偶尔表达。作者选取8例蕈样霉菌病/Sezary综合征和3例原发皮肤或伴皮肤累及的血管免疫母细胞性T细胞淋巴瘤或外周T细胞淋巴瘤,通过临床表现、组织学、免疫组化、原位分子杂交、流式细胞术及分子遗传学的比较和分析,评估蕈样霉菌病/
Follicular germinal center CD4 + helper T cells express CD10, PD-1, CXCL-13, CD57, CXCR5, SAP, BCL-6 and ICOS, and some T cell lymphomas such as angioimmunoblastic T cell lymphoma, Peripheral T-cell lymphoma with follicular growth pattern, primary cutaneous CD4 + as small T-lymphomas can express markers of follicular germinal center-assisted T cells such as CD10, nonspecific peripheral T-cell lymphoma, Transsexualized large cell lymphoma is also occasionally expressed. The authors selected 8 cases of mycosis fungoides / Sezary syndrome and 3 cases of primary immune cell or peripheral T-cell lymphoma or peripheral T-cell lymphoma with primary skin or skin involvement. The clinical manifestations, histological features, immunohistochemistry, In situ molecular hybridization, flow cytometry and molecular genetic comparison and analysis, evaluation of mycosis fungoides /