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采用Ａｍｅｓ实验和微核实验研究姜黄素的抗诱变作用，旨在为进一步研究姜黄素的抗癌作用打下基础。结果表明：姜黄素（６０～２５０微克／皿）在Ｓ－９存在的情况下能有效地控制二氨基芴所致ＴＡ９８、ＴＡ１００的回复突变；抑制率分别为２９％～５５．９％；３７．５％～５９．１％；在给环磷酰胺前，经口投与小鼠６０、１２０、２４０ｍｇ／ｋｇ姜黄素一周，每日一次。结果显示：此剂量范围内，姜黄素能明显地抑制环磷酰胺诱发的小鼠骨髓细胞微核的形成。抑制率分别为４３．９％、５６．９％、６３．９％，与阳性对照相比微核形成率有极显著性差别（Ｐ＜０．０１）。上述结果提示，应拓宽姜黄素其它生物学作用，如抗致癌作用的研究
Ames experiment and micronucleus experiments were used to study the anti-mutagenic effect of curcumin, which aims to lay a foundation for the further study of anticancer effect of curcumin. The results showed that curcumin (60-250 μg / dish) could effectively control the recovery of TA98 and TA100 induced by diaminofluorene in the presence of S-9, with inhibition rates of 29% -55.9% and 37 .5% ~ 59.1%; before giving cyclophosphamide, 60,120,240mg / kg of mouse curcumin administered orally once a day. The results showed that curcumin significantly inhibited the formation of micronuclei in bone marrow cells induced by cyclophosphamide in this dose range. The inhibitory rates were 43.9%, 56.9% and 63.9%, respectively. The micronucleus formation rate was significantly different from that of the positive control (P <0.01). The above results suggest that other biological effects of curcumin should be broadened, such as anti-carcinogenic effects