肺癌的发病率不论在国内、外均有明显上升趋势,其死亡率也和发病率一样平行上升。肺癌治疗方法、方案已成为研究的热点。化疗的应用随着新的有效药物的不断涌现和多学科治疗的发展的需要,其应用范围和重要性日见增加。多数化疗药物的效果和剂量成正比,但化疗药物的作用缺乏选择性,随着剂量的增加,其毒副反应也显著加重,其中骨髓抑制是主要的剂量限制因素。通常大剂量化疗会导致骨髓造血功能的不可逆性损伤,因而需移植造血干细胞重建造血系统,否则患者将死于骨髓衰竭和感染、出血等并发症。在过去的20年间.干细移植或支持大剂量化疗已被广 The incidence of lung cancer has a significant upward trend both at home and abroad, and its mortality rate has risen in parallel with the incidence rate. Lung cancer treatment methods and programs have become the focus of research. The application of chemotherapy With the constant emergence of new effective drugs and the need for the development of multidisciplinary therapies, the scope and importance of its application are increasing day by day. The effect and dose of most chemotherapeutic drugs are directly proportional, but the role of chemotherapeutic drugs is lack of selectivity. With the increase of dose, its toxic and side effects are also significantly aggravated, and myelosuppression is the main dose limiting factor. In general, high-dose chemotherapy causes irreversible damage to the hematopoietic function of the bone marrow. Therefore, hematopoietic stem cells need to be transplanted to rebuild the blood system. Otherwise, the patient will die from bone marrow failure, infection, and bleeding. In the past 20 years, dry transplantation or support for high-dose chemotherapy has been widely