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目的探讨白细胞介素-12(IL-12)、超敏C反应蛋白(hs-CRP)水平在新生儿感染性疾病诊断中的价值。方法将2014年2月-2016年7月在该院接受治疗的患感染性疾病的新生儿81例分为重症组(37例)和轻症组(44例),同时选取患非感染性疾病的新生儿45例作为对照组,检测各组患儿血清IL-12和hs-CRP水平。结果重症组IL-12和hs-CRP水平分别为(292.06±51.22)ng/L和(20.17±7.80)mg/L,明显高于轻症组和对照组(P<0.05);轻症组IL-12和hs-CRP水平分别为(187.81±31.40)ng/L和(7.21±2.46)mg/L,明显高于对照组(P<0.05);败血症、重症肺炎和化脓性脑膜炎患儿IL-12和hs-CRP水平比较差异无统计学意义(P>0.05);IL-12判断新生儿感染的敏感性和特异性分别为80.25%和66.66%,hs-CRP水平的敏感性和特异性分别为86.42%和75.55%,IL-12联合hs-CRP判断新生儿感染的敏感性和特异性分别为88.88%和71.11%。结论 IL-12和hs-CRP可作为新生儿感染性疾病的早期诊断指标,有效提供诊断的灵敏度或特异度,为临床诊治提供依据。
Objective To investigate the value of interleukin-12 (IL-12) and hs-CRP levels in the diagnosis of neonatal infectious diseases. Methods Eighty-two newborns with infectious diseases who were treated in this hospital from February 2014 to July 2016 were divided into severe group (n = 37) and mild group (n = 44), and non-infectious diseases 45 newborns as control group, detection of serum IL-12 and hs-CRP levels in each group. Results The levels of IL-12 and hs-CRP in severe group were (292.06 ± 51.22) ng / L and (20.17 ± 7.80) mg / L respectively, which were significantly higher than those in mild group and control group The levels of -12 and hs-CRP were (187.81 ± 31.40) ng / L and (7.21 ± 2.46) mg / L respectively, which were significantly higher than those in the control group (P <0.05) (P> 0.05). The sensitivity and specificity of IL-12 in detecting neonatal infection were 80.25% and 66.66%, respectively, and the sensitivity and specificity of hs-CRP Respectively, 86.42% and 75.55% respectively. The sensitivity and specificity of IL-12 combined with hs-CRP in determining neonatal infection were 88.88% and 71.11%, respectively. Conclusion IL-12 and hs-CRP can be used as early diagnosis indicators of neonatal infectious diseases, which can effectively provide the diagnostic sensitivity or specificity and provide the basis for clinical diagnosis and treatment.