目的:观察单唾液酸四己糖神经节苷脂钠联合纳洛酮治疗新生儿缺氧缺血性脑病的临床疗效,为新生儿缺氧缺血性脑病治疗提供新的选择。方法:将符合入组标准的84例足月新生儿缺氧缺血性脑病患儿按随机数字表分为观察组42例和对照组42例,对照组在常规治疗基础上联合纳洛酮治疗,观察组在对照组的基础上再给予单唾液酸四己糖神经节苷脂钠治疗,两组均治疗7d,观察患儿治疗前后症状改善情况,记录症状改善时间,进行新生儿神经行为评分(NBNA)评分,评判两组临床疗效,分析分娩方式对缺氧缺血性脑病的影响。结果:①观察组和对照组的显效率分别为52.38%、30.95%,观察组和对照组的总有效率分别为95.24%、73.81%,差异均具有统计学意义(P<0.05),阴道分娩和剖腹产HIE的发生率分别为0.69%、0.67%,差异无统计学意义(P>0.05);②观察组与对照组意识恢复、反射恢复、肌张力恢复、惊厥改善时间分别为(4.2±1.3)d:(7.2±2.5)d,(6.0±1.3)d:(9.0±2.2)d,(8.0±2.4)d:(10.1±3.5)d,(4.0±1.4)d:(5.5±1.8)d,观察组各项指标均短于对照组,治疗前观察组与对照组NBNA评分差异不明显,具有可比性,治疗后观察组与对照组NBNA评分分别为(37.3±10.3)分比(30.6±9.7)分,观察组评分明显高于对照组。结论:单唾液酸四己糖神经节苷脂钠联合纳洛酮能协同保护神经细胞,缩短神经损伤修复时间,加快症状改善速度,能够优化新生儿缺氧缺血性脑病现有治疗方案。 Objective: To observe the clinical efficacy of monosialotetrahexosyl ganglioside combined with naloxone in the treatment of neonatal hypoxic-ischemic encephalopathy and to provide new options for the treatment of neonatal hypoxic-ischemic encephalopathy. Methods: Eighty-four infants with full-term neonatal hypoxic-ischemic encephalopathy who met the inclusion criteria were divided into observation group (n = 42) and control group (n = 42) according to random number table. The control group was treated with naloxone . The observation group was given monosialotetrahexosyl ganglioside sodium on the basis of the control group. Both groups were treated for 7 days. The improvement of symptoms in children before and after treatment was observed. The symptom improvement time was recorded and the neonatal neurobehavioral score (NBNA) score, the clinical efficacy of two groups were evaluated, the impact of delivery mode on hypoxic-ischemic encephalopathy. Results: ① The effective rates of the observation group and the control group were 52.38% and 30.95%, respectively. The total effective rates of the observation group and the control group were 95.24% and 73.81% respectively, with statistical significance (P0.05), vaginal delivery (P> 0.05). ② The observation group and control group showed significant differences in consciousness recovery, reflex recovery, muscle tone recovery, and seizure improvement time as (4.2 ± 1.3 ) d: (7.2 ± 2.5) d, (6.0 ± 1.3) d: (9.0 ± 2.2) d, (8.0 ± 2.4) d: (10.1 ± 3.5) d, the observation group indicators were shorter than the control group, before treatment, the NBNA score was not significantly different between the observation group and the control group, the NBNA scores of the observation group and the control group were (37.3 ± 10.3) min (30.6 ± 9.7) points, the observation group score was significantly higher than the control group. CONCLUSIONS: Monosialotetrahexosyl ganglioside combined with naloxone can synergistically protect nerve cells, shorten the time of nerve injury repair, speed up the improvement of symptoms, and can optimize the existing treatment of neonatal hypoxic-ischemic encephalopathy.