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在神经系统的生长发育和损伤后再生修复的过程中,神经生长导向因子起着关键的调节作用。Slit是近年来研究发现的第一种对轴突生长和神经元胞体迁移都具有导向作用的因子,其受体是一个叫Roundabout(Robo)的跨膜蛋白[1]。对大鼠,果蝇,鸡的研究资料表明,Slit蛋白能排斥运动神经元
Nerve growth-factor plays a key regulatory role in the development and repair of nervous system after injury. Slit is the first factor discovered in recent years to play a guiding role in axonal growth and neuronal somatic cell migration. Its receptor is a transmembrane protein called Roundabout (Robo) [1]. Research data on rats, fruit flies and chickens show that Slit proteins can exclude motor neurons