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DNA修复系统是与大肠癌发病密切相关的遗传因素,错配修复基因(mismatch repair genes,MMR)是最重要的一类DNA修复基因[1],其在维护基因组稳定的细胞内通路中发挥着重要的作用,其主要是通过剪切发生错配的核苷酸而对基因进行修复[2]。散发性大肠癌的患者中有约10%可以检测到错配
DNA repair system is closely related to the pathogenesis of colorectal cancer genetic factors, mismatch repair genes (mismatch repair genes, MMR) is the most important type of DNA repair gene [1], in the maintenance of the genome stable intracellular pathways play An important role, mainly through the shear mismatched nucleotide and gene repair [2]. About 10% of patients with sporadic colorectal cancer can detect mismatches