严重的细菌性腹膜炎及腹腔内脓肿常由革兰氏阴性需氧杆菌和厌氧菌的混合感染所引起。氨基糖甙类抗生素如妥布霉素和庆大霉素对大多数葡萄球菌、肠道细菌族和绿脓杆菌有效,而林可霉素和氯林可霉素对大多数厌氧菌包括脆弱杆菌、葡萄球菌和链球菌有效。妥布霉素的副作用和过敏反应均比庆大霉素小;即使剂量增大,对肾脏损害也远比庆大霉素小。本文旨在研究严重腹腔内感染患者经高剂量妥布霉素与氯林可霉素或妥 Severe bacterial peritonitis and intra-abdominal abscess often caused by a mixed infection of gram-negative aerobic bacteria and anaerobic bacteria. Aminoglycoside antibiotics such as tobramycin and gentamicin are effective against most staphylococci, gut bacteria and Pseudomonas aeruginosa while lincomycin and clindamycin are impaired for most anaerobic bacteria Bacillus, Staphylococcus and Streptococcus effective. Tobramycin side effects and allergic reactions are smaller than gentamicin; even if the dose increases, the damage to the kidneys is also much smaller than gentamicin. This article aims to study patients with severe intraperitoneal infection by high-dose tobramycin and clindamycin or