论文部分内容阅读
目的探讨第10号染色体缺失的磷酸酶和张力蛋白同源物基因(PTEN)蛋白在喉鳞癌组织中的表达及意义。方法采用流式细胞术检测PTEN蛋白在60例喉鳞癌组织标本(A组)和30例正常喉黏膜组织标本(B组)中的表达;A组再分为有淋巴结转移组(A1组,12例)和无淋巴结转移组(A2组,48例)。结果 A组PTEN蛋白表达明显低于B组(P<0.01);临床Ⅰ+Ⅱ期喉鳞癌PTEN蛋白表达量高于Ⅲ+Ⅳ期(P<0.05);高中分化喉鳞癌PTEN蛋白表达高于低分化喉鳞癌(P<0.05);A1组患者的PTEN蛋白表达量低于A2组(P<0.01);喉鳞癌生存期大于5年的患者PTEN蛋白阳性表达率高于生存期小于5年的患者(P<0.01)。结论 PTEN蛋白可能是评价喉鳞癌预后的一个重要指标。
Objective To investigate the expression and significance of phosphatase and tensin homolog (PTEN) protein on chromosome 10 in laryngeal squamous cell carcinoma. Methods Flow cytometry was used to detect the expression of PTEN protein in 60 specimens of laryngeal squamous cell carcinoma (A group) and 30 specimens of normal laryngeal mucosa (B group). A group was divided into group with lymph node metastasis (group A1, 12 cases) and no lymph node metastasis group (A2 group, 48 cases). Results The expression of PTEN protein in group A was significantly lower than that in group B (P <0.01). The expression of PTEN in stage Ⅰ + Ⅱ laryngeal squamous cell carcinoma was higher than that in stage Ⅲ + Ⅳ (P <0.05) (P <0.05). The expression of PTEN protein in group A1 was lower than that in group A2 (P <0.01). The positive rate of PTEN protein in patients with laryngeal squamous cell carcinoma more than 5 years was higher than that in group A2 5 years of patients (P <0.01). Conclusions PTEN protein may be an important index for evaluating the prognosis of LSCC.