原发性巨球蛋白血症(简称 MGW)系由沃尔丹斯特伦(Waldenstefns)于1944年首先提出,并因为患者血清中出现大量异常巨分子球蛋白而命名。这种异常球蛋白分子量约为10~6,沉淀系数在17s 以上的巨球蛋白,正常人血清中含量甚微,均在蛋白总量的3%以下(约0.07—0.43gm/dl,平均约0.2gm/dl),若此种巨球蛋白含量超过蛋白 The primary macroglobulinemia (MGW) was first proposed by Waldenstefns in 1944 and named for the presence of a large number of abnormal macroglobulins in the patient’s sera. This abnormal globulin molecular weight of about 10 to 6, the sedimentation coefficient of 17s or more macroglobulin, normal human serum content is very small, are less than 3% of the total protein (about 0.07-0.43gm / dl, on average about 0.2gm / dl), if the macroglobulin content exceeds the protein