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目的:观察双环醇片对抗结核药物性肝损害的临床疗效。方法:将396例初治肝病患者随机分为对照组与治疗组各198例,两组均给予一线抗结核治疗,治疗组加用双环醇片保肝,对照组不加用任何保肝药物。结果:治疗9周时,治疗组肝功能损害发生率为11.1%,对照组为26.76%,两组比较差异有显著性(P>0.05)。结论:双环醇片对防治抗结核药物致肝损害有很好的效果,有利于抗结核疗程顺利完成。
Objective: To observe the clinical efficacy of bicycloalcohol tablets against tuberculosis drug-induced liver damage. Methods: 396 patients with newly diagnosed liver disease were randomly divided into control group and treatment group, with 198 cases in each group. Both groups were given first-line anti-TB treatment. The treatment group received bicyclol tablets and the control group did not use any hepatoprotective drugs. Results: At 9 weeks of treatment, the incidence of liver dysfunction in the treatment group was 11.1% and that in the control group was 26.76%. There was significant difference between the two groups (P> 0.05). CONCLUSION: Bicyclomethanol tablets have a good effect on the prevention and treatment of liver damage caused by anti-tuberculosis drugs, which is beneficial to the successful completion of anti-TB treatment.