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目的:评价右美托咪定对硬腰联合麻醉下子宫肌瘤切除手术患者术中的镇静效果的影响。方法:选择2013年1月至2016年8月在我院行子宫肌瘤切除术的患者60例,随机分为两组,每组30例。对照组患者静脉注入丙泊酚60μg/kg·h,观察组患者静脉注入右美托咪定0.4μg/kg·h。分别记录患者术前、术中30 min以及术后的Ramsay评分、BIS评分、MAP、HR以及Sp O2等生命指征和术后不良反应发生的情况。结果:实验组患者术中30 min的镇静效果优于对照组,其中Ramsay评分显著高于对照组(P<0.05),且BIS评分显著低于对照组(P<0.05)。实验组患者术中30 min HR显著低于对照组(P<0.05),但是两组之间MAP以及Sp O2却没有明显差异(P>0.05)。比较两组患者术后不良反应发生的情况发现两者差异没有明显的统计学意义(P>0.05)。结论:右美托咪定在硬腰联合麻醉下子宫肌瘤切除术患者术中可以显著改善镇静作用,值得临床上进一步推广应用。
Objective: To evaluate the effect of dexmedetomidine on the sedation of patients undergoing hysterectomy with hysterosalpingography. Methods: Sixty patients with myomectomy from January 2013 to August 2016 were randomly divided into two groups (n = 30 in each group). The control group received intravenous infusion of propofol 60 μg / kg · h and the observation group received intravenous dexmedetomidine 0.4 μg / kg · h. Ramsay score, BIS score, MAP, HR and Sp O2 and other vital signs and postoperative adverse events were recorded before operation, 30 minutes after operation and postoperatively. Results: The sedation of patients in experimental group was better than that of control group at 30 min. The Ramsay score was significantly higher than that of control group (P <0.05), and the BIS score was significantly lower than that of control group (P <0.05). The HR in the experimental group was significantly lower than that in the control group at 30 min (P <0.05), but there was no significant difference between the two groups in MAP and Sp O2 (P> 0.05). There was no significant difference between the two groups in the incidence of adverse reactions (P> 0.05). Conclusion: Dexmedetomidine can significantly improve sedation in patients undergoing hysterectomy with hysterosalpingotomy under anesthesia, which deserves further clinical application.